Week 13: November 30, 2008 at Cleveland Browns Stadium in Cleveland, Ohio.
The Colts needed a 37-yard fumble return for a touchdown by Robert Mathias late in the fourth quarter to beat the Browns 10-6. Mathias also had two sacks. Indianapolis QB Peyton Manning tossed two interceptions and threw for only 125 yards in the win, the Colts' fifth straight. For Cleveland, QB Derek Anderson was injured on the final drive and sprained his MCL, whcih sidelined him for the rest of the season.