Week Five: October 5, 2008 at Candlestick Park in San Francisco, California.
New England 30, San Francisco 21.
The Patriots win their first ever game in San Francisco (0-4 in four previous games) thanks to a 111-yard receiving performance by Randy Moss, inclduing a 66-yard touchdown. For the 49ers, linebacker Patrick Willis recorded 18 tackles and a sack.