The structure was designed by architect Frank Gehry, who accepted the design commission in April 1999; the pavilion was constructed between June 1999 and July 2004, opening officially on July 16, 2004.

Pritzker Pavilion serves as the centerpiece for Millennium Park and is the new home of the Grant Park Symphony Orchestra and Chorus and the Grant Park Music Festival, the nation's only remaining free outdoor classical music series. It also hosts a wide range of music series and annual performing arts events. Performers ranging from mainstream rock bands to classical musicians and opera singers have appeared at the pavilion, which even hosts physical fitness activities such as yoga. All rehearsals at the pavilion are open to the public; trained guides are available for the music festival rehearsals, which are well-attended.