Rosalie Mansion is a historic pre-Civil War mansion in Natchez, Mississippi, significant for its Greek Revival style influence on Antebellum architecture in the greater region. During the American Civil War, it served as Union headquarters for the Natchez area from July 1863 on.

Rosalie Mansion has been owned, operated, and maintained as a historic house museum by the Mississippi State Society Daughters of the American Revolution, for more than seventy years.