Quoted from Wikipedia:
Acre or Akko is a city in the Western Galilee region of northern Israel at the northern extremity of Haifa Bay. Acre is one of the oldest continuously inhabited sites in the country.

Historically, it was a strategic coastal link to the Levant. Acre is the holiest city of the Bahá'í Faith. In 2009, the population was 46,300. Acre is a mixed city, 72 percent Jewish and 28 percent Arab.
Acre is one of the oldest continuously inhabited sites in Israel. The name Aak, which appears on the tribute-lists of Thutmose III (c. 16th century BC), may be a reference to Acre. The Amarna letters also mention a place named Akka, as well as the Execration texts, that pre-date them. In the Hebrew Bible, (Judges 1:31), Akko is one of the places from which the Israelites did not drive out the Canaanites. It is later described in the territory of the tribe of Asher and according to Josephus, was ruled by one of Solomon's provincial governors. Throughout Israelite rule, it was politically and culturally affiliated with Phoenicia. Around 725 BC, Akko joined Sidon and Tyre in a revolt against Shalmaneser V.

Following the defeat of the Byzantine army of Heraclius by the Muslim army of Khalid ibn al-Walid in the Battle of Yarmouk, and the capitulation of the Christian city of Jerusalem to the Caliph Umar, Acre came under the rule of the Arab caliphate beginning in 638. The Arab conquest brought a revival to the town of Acre, and it served as the main port of Palestine through the Umayyad and Abbasid Caliphates that followed, and through Crusader rule into the 13th century. It was captured by King Baldwin I of Jerusalem in 1104 in the First Crusade and the Crusaders also made the town their chief port in Palestine. Around 1170 it became the main port of the eastern Mediterranean, and the kingdom of Jerusalem was regarded in the west as enormously wealthy above all because of Acre. According to an English contemporary, it provided more for the Crusader crown than the total revenues of the king of England. It was re-taken by Saladin in 1187, and unexpectedly besieged by Guy of Lusignan reinforced by Pisan naval and ground forces at first, in August 1189. But it was not captured until July 1191 by Richard I of England, Philip of France, Leopold of Austria, the spearhead Swabian and German armies and the rest of the crusader's army. It then became the capital of the remnant of the Kingdom of Jerusalem in 1192. In 1229 it was placed under the control of the Knights Hospitaller. The Crusaders called the city "Acre" or "Saint-Jean d'Acre" since they mistakenly identified it with the Philistine city of Ekron[in northern Philistia, now southern Israel. It was the final stronghold of the Crusader state, and fell to the Mameluks of Egypt in a bloody siege in 1291.

The Ottoman Turks under Sultan Selim I captured the city in 1517, after which it fell into almost total decay. English academic Henry Maundrell in 1697 found it a ruin, save for a khan (caravanserai) occupied by some French merchants, a mosque and a few poor cottages.