Located at the corner of Market and Fort Streets on Mackinac Island.
At right is Trinity Episcopal Church.

Fur trading was prevalent starting in 1680.
The AFC started business in 1820.
On the web, we learn the following:

"On this site in 1822 Alexis St. Martin, a voyageur, was injured by an accidental gunshot wound.
The unusual healing of the wound allowed Dr. William Beaumont, Fort Mackinac’s post surgeon,
to conduct experiments on how the human stomach worked."