The interior is splendid with detailed Mudejar decorations on the walls throughout. Some of the rooms, such as the Praetor's Room and Praetor's Study have elaborately decorated coffered ceilings.
A staircase, considered one of the most magnificent in all of Seville, connects the ground floor with the upper floor where you can find several furnitured rooms with pieces from the art collection of the Medinaceli. The upper floor however can only be visited on a guided tour.