The Cathedral Basilica of Saints Cosmas and Damian (Parrocchia Santuario Basilica S. S. Cosma E Damiano).
Also called Basilica Santi Medici.

In 1609, a chapel dedicated to Our Lady of Grace existed in Alberobello; veneration of Saints Cosmas and Damian is attested from 1636.
Beginning in 1725, the church was expanded.
Between 1881 and 1885, the façade was rebuilt according to the design of the architect Antonio Currie, and then the rest of the church was renovated according to his design.
The parish church was declared a sanctuary on September 12, 1938, and in 2000, the church was granted the title of minor basilica.