La Boca retains a strong European flavour, with many of its early settlers being from the Italian city of Genoa. In fact the name has a strong assonance with the Genoese neighborhood of Boccadasse (or Bocadaze in Genoese dialect), and some people believe that the Buenos Aires barrio was indeed named after it. In 1882, after a lengthy general strike, La Boca seceded from Argentina, and the rebels raised the Genoese flag, which was immediately torn down personally by then President Julio Argentino Roca.
But the name stuck as you can see!