Paul - I have found that my 80D with a new designed sensor has a noise profile that is mostly shot noise, and so both Lightroom and Topaz DeNoise deal with it very well. For this one I used Topaz DeNoise, which has no CA correction. I also did not apply CA correction in LR, as I didn't see any to correct.
5000 ISO, that's pretty good for 5K. You must have a great NR process that also controls the CA. I do see some after effects of CA here and there. Thumbs up. Paul
