This station was built in 1912 and was served by the Denver and Rio Grand Railroad. The rail yard, now mostly abandoned, was once the center of all the activity in town. Scattered around the depot, the old original buildings and abandoned factories tell tales of the past. One can almost see the ghosts of the workers loading sacks of potatoes and onions onto the train. Montrose was a dual gauge yard from 1887 to 1953. Narrow Gauge tracks went out of Montrose south to Ridgway and East to Cimarron. Standard Gauge went north to Grand Junction. The tracks to Ridgway were converted to standard gauge in the 1950's after the Ouray Branch was removed and the Rio Grand Southern was abandoned. Today the line is still standard gauge and operated to Grand Junction.

The station is no longer in use as a passenger station but is utilized as a museum.