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Following the First Council of Nicaea in AD 325 construction of a hospital in every cathedral town was begun, including amongst the earliest health centers by Saint Sampson in Constantinople and by Basil, bishop of Caesarea in modern-day Turkey. By the twelfth century, Constantinople had two well-organised medical facilities, staffed by physicians who were both male and female.

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Entryway to the Qalawun complex in Cairo, Egypt which housed the significant Mansuri healthcare facility. The earliest general healthcare facility in the Islamic world was constructed in 805 in Baghdad by Harun Al-Rashid. By the 10th century, Baghdad had 5 more health centers, while Damascus had 6 healthcare facilities by the 15th century, and Crdoba alone had 50 significant health centers [], numerous exclusively for the armed force.

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It generally dealt with the poor, as the abundant would have been treated in their own houses. Medical facilities in this era were the first to require medical diplomas to license medical professionals, and settlement for carelessness could be made. [] Healthcare facilities were prohibited by law to turn away patients who were unable to pay. [] These medical facilities were economically supported by waqfs, as well as state funds.

In Europe the medieval principle of Christian care evolved during the sixteenth and seventeenth centuries into a nonreligious one. In England, after the dissolution of the monasteries in 1540 by King Henry VIII, the church suddenly stopped to be the fan of health centers, and just by direct petition from the people of London, were the medical facilities St Bartholomew's, St Thomas's and St Mary of Bethlehem's (Bedlam) endowed straight by the crown; this was the first circumstances of nonreligious assistance being provided for medical institutions.

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Hoare & Co and Man's Health center (1724) moneyed from the bequest of the rich merchant, Thomas Guy. Other hospitals sprang up in London and other British cities over the century, numerous spent for by private subscriptions. A Good Read 's in London was reconstructed from 1730 to 1759, and the London Healthcare Facility, Whitechapel, opened in 1752.

Some of the era's greatest surgeons and physicians worked and handed down their knowledge at the hospitals. They also changed from being simple houses of refuge to being complex institutions for the arrangement of medicine and look after sick. The Charit was founded in Berlin in 1710 by King Frederick I of Prussia as a response to an outbreak of afflict.