Fort Clatsop was the encampment of the Lewis and Clark Expedition in the Oregon Country near the mouth of the Columbia River during the winter of 1805-1806. Fort Clatsop was named after the local Clatsop tribe of Native Americans.

In the late evening of October 3, 2005, a fire destroyed the replica fort. A 9-1-1 operator's insistence that the fire was no more than fog over the nearby Lewis and Clark River delayed firefighters’ arrival by about 15 minutes, possibly impacting their ability to save part of the structure. Investigators found no evidence of arson.