The Alabama Hills are a popular filming location for television and movie productions, especially Westerns set in an archetypical "rugged" environment. Since the early 1920s, 150 movies and about a dozen television shows have been filmed here, including Tom Mix films, Hopalong Cassidy films, The Gene Autry Show, The Lone Ranger and Bonanza. Classics such as Gunga Din, The Walking Hills, Yellow Sky, Springfield Rifle, The Violent Men, Bad Day at Black Rock, the Budd Boetticher/Randolph Scott "Ranown" westerns, part of How the West Was Won, and Joe Kidd. In the late 1940s and early 50s the area was also a popular location for the films of B-western actor Tim Holt.

More recent productions such as Tremors and Joshua Tree, were filmed at "movie ranch" sites known as Movie Flats and Movie Flat Road. In Gladiator, actor Russell Crowe rides a horse in front of the Alabamas, with Mount Whitney in the background, for a scene presumably set in Spain. Star Trek Generations was filmed here in addition to Overton, Nevada and Paramount Studios. This range was one of the filming locations for Disney's Dinosaur. More recently, many parts of the films Iron Man and Transformers: Revenge of the Fallen were filmed here.