The oldest mentioning of Molsbroek we find in the charter of the abbey of Boudeloo (November 1281). There we find in the archives the first name of "Hof te Mosbrouc".
In the middle-ages and maybe before this area was hay-and pastureland . But the farmers left as they builded dykes along the river Durme and Molsbroek next to it was only used to capture the water by flood of the river to protect the city Lokeren.
Only in 1981 got this landscape his patronage as a recognized nature-reserve.