Tested 3 different noise removal programs... Topaz DeNoise AI, DXO Photolab 4 Deep Prime and the new On1 NoNoise AI. This was a RAW file from my Sony A1 edited in each program directly and saved as a TIF then converted to a JPG for here.

All the programs were set to Auto. Of course, adjustments can be made manually to all of them to improve the end result but you can say that for any program. This is to see how well they do on their default settings which also means the quickest processing time.