An experiment in "ISO-less" using a Nikon D7200. Images were taken at ISO 200 - ISO 12800 using f8.0 and 1/5 second exposure. ISO 1600 was 'properly exposed'

Here's what I did in PS CS5 ACR 6.7.xx, sharpening all the way down:

1. Open the reference ISO 1600 File that was properly exposed using all ACR defaults EXCEPT I used the Camera profile 'Camera Flat' instead of 'Adobe standard' in Camera Calibration and process 2010.
2. Open the other ISO variant files at ACR defaults EXCEPT I used camera profile 'Camera Flat', process 2010 (2012 is unavailable) AND dialed in the appropriate exposure compensation. This varied from -3.0 EV for ISO 200 to +3 EV for ISO 12800.

The concept "ISO-less" works at mundane ISO settings when we use the same exposure settings, in this case f8.0 and 1/5 second for all images.
Conceptually the only difference taking place is the utilization of the EXIF (?) annotation to process the image properly in or out of camera. The days of additional 'boost' across all ISO are gone apparently.

These are all 100% crops out of 24MP files. Here we have ISO 200, ISO 1600, ISO 3200. ISO 6400, and ISO 12800. I skipped ISO 400 and ISO 800 because they are evidently the same as 200 and 1600.
ISO 3200 is extremely similar to 1600 and below but there is noticable changes at ISO 6400 and a significant shift at ISO 12800.
This illustrates what I expected; that "ISO-less" works at garden variety settings but at the extremes, other things are taking place.

By far the best way to see differences in these crops is to layer/stack them in an image editor like Photoshop and toggle each layer on and off to A&B them. Obviously this is not practical on the web.

The image is 'washed out" because of the 'Camera Flat' setting used in ACR and, while irrelevant in this case', is easily changed.

To prepare this JPeg, I originally stacked these images in Photoshop starting with ISO 12800 and thus that EXIF data