Yellowstone National Park, the world's first national park, was established on March 1, 1872. In the park's early years, a civilian staff (with limited financial and human resources) was in charge of running and protecting the park. However, the civilian group was unable to protect the park's natural features and wildlife, so in 1886, control over the park was delegated to the United States Army. After the Battle of Little Bighorn, the army had established a "Yellowstone Department" in the area to control the Sioux.

The Army set up a tent camp near Mammoth Hot Springs, which eventually evolved into Fort Yellowstone, which the army continued to use until they turned over control of the park (and the fort) to the then newly-formed National Park Service in 1918. The National Park Service used Fort Yellowstone as Yellowstone National Park's headquarters, which has continued to this day.

Fort Yellowstone was designated a National Historic Landmark on July 31, 2003.