Sacred Datura

A poisonous perennial plant species and ornamental flower of the family Solanaceae native to the Southwestern United States and northwestern Mexico. It is sometimes used as a hallucinogen due to its psychoactive alkaloids.
All parts of Datura plants contain dangerous levels of anticholinergic tropane alkaloids and may be fatal if ingested by humans, livestock, or pets. In some places, it is prohibited to buy, sell or cultivate Datura plants.
Among the Zuni people, the powdered root is given as an anesthetic and a narcotic for surgery. They also apply a poultice of root and flower meal applied to wounds to promote healing. The Zuni used Datura as a way to render patients unconscious while broken bones were set.

source: wikipedia - edited by me