The interior of Sta. Maria Novella is designed on a Latin Cross plan where
the llonger arm of the cross creates the space for the nave, and shorter arm enclosing the altar area and side chapels.
Alberti's design for the facade (previous image), corresponds to the central higher ceiling of the nave
and lower side aisles seen in this picture.

Behind the altar area in the background, is the Tournabouni Chapel, which contains the Ghirlandaio
frescoes (1485-1490) showing scenes from the Life of the Virgin on the left wall,
and the Life of John the Baptist on the right wall.

A Giotto Crucifix (1289) hangs high separating the nave from the altar area..
Brunelleschi also carved and painted a Crudifix (1410-15) hanging to the left of the altar in the Gondi Chapel.
The most famous fresco in the church, Masaccio's "Holy Trinity Fresco" can be seen on the left side of the nave.
(See next picture)
It is interesting to note that Duccio's "Enthroned Madonna and Child", and better known as the "Ruccellai Madonna"
now in the Uffizi, was commissioned by the Ruccellai family, was originally in the family's chapel in Sta. Maria Novella.