The mountain is mentioned for the first time in the Hebrew Bible, in Joshua 19:22, as border of three tribes: Zebulun, Issachar and Naphtali. The mountain's importance stems from its strategic control of the junction of the Galilee's north-south route with the east-west highway of the Jezreel Valley. Deborah the Jewish prophetess summoned Barak of the tribe of Naphtali and gave him God's command, "Go and draw toward mount Tabor, and take with thee ten thousand men of the children of Naphtali and of the children of Zebulun" (Judges 4:6). Descending from the mountain, the Israelites attacked and vanquished Sisera and the Canaanites.

Between 1919 until 1924 an impressive Roman Catholic church of the Franciscan order named "Church of the Transfiguration" was built on the peak of Mount Tabor. The architect who designed the church, as well as other churches in Israel, was Antonio Barluzzi. The church was built upon the ruins of a Byzantine church from the fifth or sixth century and a Crusader church from the 12th century, which was built in honor of Tancred, Prince of Galilee. The friars of the church live next to the church in a monastery established in 1873.