The monastery was probably founded in the Middle Ages, during the occupation of Crete by the Republic of Venice, its founder being a feudal lord named Prevelis. It developed over several centuries as a religious and cultural centre for the local population. After the Ottoman Turkish occupation of the island, Abbot Melchissedek Tsouderos led a group of rebels in the Greek War of Independence in 1821, one result of which was that the monastery was destroyed, but later rebuilt. In 1866 and 1878, the monastery was again active in organising rebellions against the Turks, which helped contribute to Crete's eventual independence and then its political union with Greece.