The Buffalo and Pittsburgh Railroad (reporting mark BPRR) is a Class II railroad[1] operating in New York and Pennsylvania.

The BPRR is owned by Genesee and Wyoming Industries and runs between Buffalo, New York and Eidenau, Pennsylvania (north of Pittsburgh). It runs largely on former Baltimore and Ohio Railroad (B&O) lines. The entire BPRR system is 411 miles.

Major commodities carried include paper, petroleum products, chemicals, coal, steel, and sand.