The Gamble House, also known as David B. Gamble House, is a National Historic Landmark, a California Historical Landmark, and museum in Pasadena, California, USA. It was designed by brothers Charles Sumner Greene and Henry Mather Greene of the architectural firm Greene and Greene and constructed 1908–09 as a home for David B. Gamble of the Procter & Gamble company.

Originally intended as a winter residence for David and Mary Gamble, the three-story Gamble House is commonly described as America's Arts and Crafts masterpiece.