'Don't drink and drive' signs are among the more interesting ones. The various approaches are fascinating.
The people of Artesia, New Mexico speak in terms that everyone can understand: Drive Sober! Texas and Pennsylvania both warn that "you can't afford it[,]" apparently directed to the less affluent denizens. In Middleburg, Indiana, drivers are told "Don't Drink and Drive[,]" but below that appears the sponsorship of Park Pharmacy, perhaps implying that motorists should use pharmaceuticals instead. Then there's that creepy bat sign in Oklahoma or New Mexico (the location escapes me) which cautions ominously that there are "checkpoints everywhere." In California, the sign warns that if you're caught driving while impaired, you'll lose not just your license, but your car, too. Bloomington, Indiana advises not that drunk driving is unlawful, but rather that you are not permitted to have open beer cans in your car. In Socorro and Hobbs, New Mexico, the approach is to ask nicely: "Please don't drink and drive."
And then there's New Hampshire, which advertises a liquor store two miles up the road.