Oprah Winfrey as Mrs. Which
Mindy Kaling as Mrs. Who
Reese Witherspoon as Mrs Whatsit

Other Cast of "A Wrinkle in Time"
Storm Reid as Meg
Gugu Mbatha-Raw as Dr. Kate Murry
Michael Pena as Red
Zach Galifianakis as Happy Medium
Chris Pine as Dr. Alex Murry