Truxton originally developed around a gas station and cafe along Route 66 in 1951. The name of the town comes from the famous Beale Camel Expedition. Lieutenant "Ned" Beale stopped at the spring here in 1857 and named it Truxton in honor of either his brother Truxton or his mother, Emily Truxton Beale. Once bypassed by the Interstate, Truxton became a mere shell of the town.

Peach Springs got its name from the peach trees found growing by the spring here. Because the steam locomotives used water from the spring a water tank and station were built by the railroad here. A town grew up around the station and by 1883 it was said to have ten saloons but no schools or churches.Today Peach Springs is the administrative headquarters of the Hualpai Indian Nation. In the hey day of Route 66 there were many motor courts, cafes and assorted tourist related businesses operating out of Peach Springs. When the Interstate bypassed Peach Springs, the town still held on. Not much is left of the Route 66 businesses in Peach Springs today though except for a few abandoned stone buildings and a classic old garage that was built in 1923.