Originally called Camp Calhoun the site was used as an army post beginning in 1849. Fire destroyed the original buildings. Eventually transferred to the Department of the Interior and the Quechan tribe in 1884, it became a boarding school run by the Catholic Church until 1900. Today the Quechan Tribe (Yuma) uses most of the buildings.
The building in the photo is most probably the old Quartermaster Building. It was refurbished about 30 years ago but right now it is all boarded up and closed to the public.
Fort Yuma is a California Registered Historical Landmark.