Between July 1942 and September 1944, almost every Tuesday a cargo train left for the concentration camps Auschwitz-Birkenau (65 train-loads containing 60,330 people most of whom were gassed on arrival), Sobibór (19 train-loads of 34,313 people, all of whom were killed on arrival), Bergen-Belsen and Theresienstadt (9 train-loads of 4,894 people some 2,000 of whom survived the war). In the period from 1942 to 1945, a total of 107,000 people passed through the camp on a total of 93 outgoing trains. Only 5,200 of them survived, most of them in Theresienstadt or Bergen-Belsen, or were liberated at Westerbork.

Anne Frank stayed in hut 67 (See picture AF) from August until early September 1944, when she was taken to Auschwitz. She and her family were put on the first of the three final trains (the three final transports were most probably a reaction to the Allies' offensive) on 3 September 1944 for Auschwitz, arriving there three days later.