September 30, 2007 at Qualcomm Stadium in San Diego, California.
The Chiefs outscore the Chargers 24-0 in the second half to win 30-16. LaDanian Tomlinson rushes for 132 and a touchdown, while Larry Johnson goes for 123 yards on the ground. Philip Rivers tossed two interceptions and fumbled once that was returned for a touchdown in the San Diego loss. Kansas City rookie wide receiver Dwayne Bowe set a team-rookie record with 164 yards, including a 51-yard touchdown.