November 1, 2008 at the Metrodome in Minneapolis, Minnesota.
Northwestern 24, Minnesota 17. The 17th-ranked Gophers were upset on homecoming thanks to a Brendan Smith 48-yard interception return for a touchdown with 12 seconds left on the clock. Wildcats QB Mike Kafka ran for 217 yards and passed for another 143. He tossed two scores. Gophers QB Adam Weber tossed for 327 yards and ran for 51 more in a losing effort.