Sept. 12, 2010 at Reliant Stadium in Houston, Texas.
Texans 34, Colts 24. Houston running back Arian Foster rushed a team-record 33 times for a team-record 231 yards with a team-record-tying three rushing touchdowns in just the Texans' second win ever against the Colts. Indy QB Peyton Manning set career bests in completions and attempts while having his eighth career 400-yard passing game (tied for second most in NFL history).