The Amoxil generic name is amoxicillin, a semi-synthetic antibiotic derived from the penicillin core structure. This guide explores the scientific and regulatory aspects of amoxicillin's nomenclature, bioequivalence standards, and global naming variations.

Chemical Structure and Naming

Nomenclature Type	Designation	Significance
IUPAC Name	(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid	Precise molecular description
INN (International Nonproprietary Name)	Amoxicillin	WHO-standardized global name
USAN (United States Adopted Name)	Amoxicillin	Official FDA designation

Bioequivalence Standards

• FDA Requirements:
  
  
  
  • 90% confidence interval of 80-125% for AUC and Cmax
  
  
  • Same active ingredient, strength, and dosage form
  
  
  
  


• Clinical Equivalence:
  
  
  
  • No significant difference in therapeutic effect
  
  
  • Identical adverse reaction profiles
  
  
  
  

Global Brand-Generic Variations

International Equivalents

• United Kingdom: Amoxil (GSK), Rimoxallin (generic)


• Canada: Apo-Amoxi, Novo-Amoxin


• Australia: Alphamox, Amoxil

Formulation Differences

• Excipient variations:
  
  
  
  • Brand: May use proprietary coatings
  
  
  • Generic: Must use approved alternatives
  
  
  
  


• Bioavailability equivalence:
  
  
  
  • All meet strict regulatory standards
  
  
  • ±5% absorption difference allowed
  
  
  
  

Cost Comparison

• Brand-name: $50-$100 per course


• Generic: $4-$20 per course


• Insurance coverage:
  
  
  
  • 90% prefer generics
  
  
  • Often $0 copay for generic amoxicillin
  
  
  
  

Pharmacological Identity

• Molecular formula: C₁₆H₁₉N₃O₅S


• Molecular weight: 365.4 g/mol


• CAS number: 26787-78-0

Conclusion

Understanding that the Amoxil generic name is amoxicillin ensures patients and providers can confidently use cost-effective alternatives. All FDA-approved generic versions maintain identical therapeutic efficacy to the brand-name product, with rigorous standards ensuring comparable safety and effectiveness across international markets.