When cold sores appear, acyclovir ointment acts like a protective shield you apply directly to the affected area. Unlike pills that work through your whole system, this cream targets the problem spot directly. Here's what makes it different and when it works best.

How the Ointment Works on Your Skin

The ointment version of acyclovir works through a simple but effective process:

1. Creates a protective barrier - Forms a medicinal layer over the sore


2. Absorbs into infected skin cells - Penetrates where the virus is active


3. Blocks virus multiplication - Stops the sore from growing larger


4. Reduces healing time - Can shorten outbreaks by 1-2 days when used early

When to Choose Ointment Over Pills

Situation	Ointment Advantage
Small, localized cold sores	Direct treatment without systemic effects
Early tingling stage	Can prevent blister formation
For people who can't swallow pills	Easy topical application
When avoiding drug interactions	Minimal absorption into bloodstream

Step-by-Step Application Guide

For best results:

1. Wash hands thoroughly


2. Clean affected area gently with water


3. Dry completely with clean tissue


4. Use a cotton swab or finger cot to apply pea-sized amount


5. Rub in gently until absorbed


6. Wash hands again after application


7. Repeat 5 times daily (about every 4 hours while awake)

What to Expect During Treatment

• Day 1: Tingling/itching may decrease


• Day 2-3: Blister may stop growing or start shrinking


• Day 4-5: Scabbing begins, pain lessens


• Day 7-10: Complete healing typically occurs

Important Safety Tips

• Avoid eyes and mouth - For external lip area only


• Don't share tubes - Prevents spreading infection


• Watch for irritation - Rare but possible skin reactions


• Check expiration dates - Effectiveness decreases over time

For comprehensive information about this topical treatment, see acyclovir ointment options and proper use guidelines.

Frequently Asked Questions

Can I use makeup over the ointment?

Wait 15 minutes after application before applying any cosmetics.

Is it safe during pregnancy?

Topical acyclovir has minimal absorption, but always consult your doctor first.

Why does my tube say "not for genital herpes"?

The ointment formulation isn't designed for mucosal surfaces - use cream instead.

Real User Experiences

"I keep acyclovir ointment in my purse and apply it at the first tingle. About half the time, the cold sore never even appears." - Jenna, 31

"The ointment helps more with the pain than the pills alone. I use both when I get a bad outbreak." - Mark, 45

Key Advantages

• Directly targets affected area


• Minimal side effects


• Convenient for on-the-go use


• Works best when combined with early detection