In its Spanish section, the Douro crosses the great Castilian meseta and meanders through five provinces of the autonomous community of Castile and León: Soria, Burgos, Valladolid, Zamora, and Salamanca, passing through the towns of Soria, Almazán, Aranda de Duero, Tordesillas, and Zamora.
In this region, there are few tributaries of the Douro. The most important are the Pisuerga, passing through Valladolid, and the Esla, which passes through Zamora. This region is generally semi-arid plains, with wheat and in some places, especially near Aranda de Duero, with vineyards, in the Ribera del Duero wine region. Sheep rearing is also still important.